The protective effect of selenium nano-particles against mono-sodium glutamate-induced alterations in male albino rats.

Background: Monosodium glutamate (MSG) is a flavor enhancer that is frequently used in food, particularly in Asian and West African cuisines. It is created during the fermentation of starch, sugar, beet sugarcane, or molasses. Some reports claim that MSG is harmful to both humans and animals. Objective: This study aims to investigate the protective effect of selenium nano-particles on testicular toxicity induced by mono-sodium glutamate in male albino rats. Method: The experiment was performed on 28 Wistar male rats; the experimental study include 4 groups (7 rats each): G1:control rats fed normal rodent diet and water; G2: rats received selenium nano-particles at a dose of (0.4 mg/kg bwt) for 28 days, G3: Male albino rats received mono-sodium glutamate in a daily dose of (4 g/kg bwt) for 28 days intraperitoneally;G4: Male albino rats received a daily oral dose of Se-NPs for 7 successive days & on the 7th day the animals received the first dose of MSG intraperitoneally (4g/kg bwt) then rats received both treatments until the end of the experiment for 28 days. Serum Testosterone hormone, serum lipid peroxidation [MDA], reduced glutathione [GSH] were estimated, samples from testis were separated for histological analysis. Result: The results of the following study revealed that the administration of Se-NPs orally before MSG treatment resulted in a protective effect against testicular toxicity as it resulted in a significant decline in the levels of serum MDA, elevation in the values of serum GSH level and testosterone, improvement in testicular architecture & reappearance of sperms. Conclusion: The results showed that Se-NPs treatment as a protector exhibited a protective effect against testicular damage and enhance antioxidant status in male albino rats.