Design, Characterization and Molecular Docking Study of the New Isoxazolidine-1,2,3-Triazole Hybrids

Kaiss Aouadi; Alsowayan Raghad; Siwar Ghannay; Sabri Messouadi; Adel Kadri

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Research Article

3 (

); 83-93

Design, Characterization and Molecular Docking Study of the New Isoxazolidine-1,2,3-Triazole Hybrids

Kaiss Aouadi, Alsowayan Raghad, Siwar Ghannay, Sabri Messouadi, Adel Kadri

Received: 2023-12-03, Accepted: 2023-12-23, Published: 2024-10-27

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This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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This article was originally published by Qassim University and was migrated to Scientific Scholar after the change of Publisher.

Abstract

Polycyclics are considered among the most widely used compounds in drug discovery. Isoxzolidine-triazole hybrids have multiple medicinal properties, including anti-inflammatory and anti-tumor agents. In this work, we synthesized a new series of isoxazolidine-triazole hybrids and study molecular docking of the synthesized compounds to determine the binding interactions with target protein PIKα (PDB ID: 3ZIM). With a docking score of -10.4 kcal/mol, 7e demonstrated good binding affinity to the active site of PI3K among all synthesized compounds.