1,2,4-Triazole as promising scaffold: Synthetic and Biological Aspects

Danyah Al-Elweet; Wael El-Sayed; Fahad M. Alminderej; Abuzar E. A. E. Albadri

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Research Article

2 (

); 61-94

1,2,4-Triazole as promising scaffold: Synthetic and Biological Aspects

Danyah Al-Elweet, Wael El-Sayed, Fahad M. Alminderej, Abuzar E. A. E. Albadri

Received: 2023-06-01, Accepted: 2023-06-19, Published: 2024-01-28

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This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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This article was originally published by Qassim University and was migrated to Scientific Scholar after the change of Publisher.

Abstract

1,2,4-triazoles are valuable scaffolds in medicinal chemistry due to their diverse biological activities. This review delves into synthesis strategies, such as iodine-mediated, microwave-assisted, solid-phase, and liquid-phase approaches, and their biological relevance. These methods yield efficient access to 1,2,4-triazoles, which demonstrate significant anticancer, anti-inflammatory, antimicrobial, antioxidant, and antiviral properties. Additionally, carbohydrate-based triazoles and coumarin-azole-sugar hybrid compounds also show remarkable activity. The potential of 1,2,4-triazoles in drug discovery and therapeutic applications underscores their role in medicinal chemistry.